Synthesis of 3-Trifluoromethyl- and 3-Perfluoroalkyl-Substituted 3-Aryloxy- and 3-Heteroaryloxypropenoic Acids and of the Cyclization Products, 2-Trifluoromethyl- and 2-Perfluoroalkyl-4H-chromen-4-ones

Salem El Kharrat; Rouba El Kharrat; Philippe Laurent; Hubert Blancou

doi:10.1055/s-2007-990861

PAPER

Synthesis of 3-Trifluoromethyl- and 3-Perfluoroalkyl-Substituted 3-Aryloxy- and 3-Heteroaryloxypropenoic Acids and of the Cyclization Products, 2-Trifluoromethyl- and 2-Perfluoroalkyl-4H-chromen-4-ones

Salem El Kharrat, Rouba El Kharrat, Philippe Laurent*, Hubert Blancou
UMR-CNRS 5247 Matériaux Fluorés Synthèses et Applications, Université Montpellier, 2 c.c.1706, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France
Fax: +33(4)67631046; e-Mail: philippe.laurent@univ-montp2.fr;

Abstract

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Abstract

We describe a novel and simple method for the regiospecific synthesis of functionalized trifluoromethyl- and perfluoroalkyl-containing 4H-chromen-4-ones via the cyclization of substituted 3-aryloxy-3-perfluoroalkylpropenoic acids. The procedures give the final products in high yields, without any need for chromatographic purification, and no side products.

Key words

aldehydes - oxidations - carboxylic acids - regioselectivity - heterocycles

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References

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